Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 1/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | MTOR | P42345 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14525248 | 0.93 | HTR1B (0.74) | HTR1BKCNH2ALDH1A1MAPTLMNA | |
| SCHEMBL14526632 | 0.90 | HTR1B (0.63) | HTR1BKCNH2ALDH1A1MAPTLMNA | |
| SCHEMBL14529939 | 0.90 | HTR1B (0.62) | HTR1BKCNH2ALDH1A1MAPTLMNA | |
| SCHEMBL14525249 | 0.90 | HTR1B (0.68) | HTR1BKCNH2RAD52SMN1; SMN2 | |
| SCHEMBL14525296 | 0.89 | HTR1B (0.64) | HTR1BKCNH2ALDH1A1MAPTLMNA | |
| SCHEMBL4246219 | 0.88 | HTR1B (0.84) | HTR1BKCNH2ALDH1A1MAPTMEN1 | |
| SCHEMBL14525295 | 0.87 | HTR1B (0.62) | HTR1BKCNH2ALDH1A1MAPTLMNA | |
| SCHEMBL14525293 | 0.87 | HTR1B (0.62) | HTR1BKCNH2ALDH1A1MAPTLMNA | |
| SCHEMBL14529635 | 0.87 | HTR1B (0.60) | HTR1BKCNH2ALDH1A1MAPTLMNA | |
| SCHEMBL14530023 | 0.87 | HTR1B (0.65) | HTR1BKCNH2ALDH1A1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007053095-A1 | CHROMAN COMPOUNDS AS 5-HT1B ANTAGONISTS | ASTRAZENECA AB (SE) | 2007-05-10 | — | — | WO | disclosed |