Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 14/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.54 |
| ▸ | MEN1 | O00255 | 8/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | MET | P08581 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 7/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8239208 | 0.72 | HTT (0.71) | MAPTKMT2AMEN1TDP1LMNA | |
| SCHEMBL4408424 | 0.68 | MAPT (0.68) | MAPTKMT2AMEN1TDP1LMNA | |
| SCHEMBL13497056 | 0.67 | MAPT (0.76) | MAPTKMT2AMEN1TDP1LMNA | |
| SCHEMBL4326725 | 0.62 | MEN1 (1.00) | MAPTKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL4326729 | 0.62 | MEN1 (1.00) | MAPTKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL12417172 | 0.61 | MAPT (1.00) | MAPTKMT2AMEN1LMNAPOLB | |
| SCHEMBL4323309 | 0.60 | MAPT (1.00) | MAPTKMT2AMEN1LMNAPOLB | |
| SCHEMBL4323306 | 0.60 | MAPT (1.00) | MAPTKMT2AMEN1LMNAPOLB | |
| SCHEMBL12417168 | 0.60 | MAPT (0.82) | MAPTKMT2AMEN1TDP1LMNA | |
| SCHEMBL12819601 | 0.60 | KDM4E (0.48) | MAPTKMT2AMEN1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1790345-A1 | Triazin beta-secretase inhibitors | Esbatech AG (CH) | 2007-05-30 | — | — | EP | disclosed |