Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 5/20 | 0.71 |
| ▸ | MAPT | P10636 | 12/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.64 |
| ▸ | MEN1 | O00255 | 9/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.64 |
| ▸ | CRHBP | P24387 | 2/20 | 0.64 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.64 |
| ▸ | NPC1 | O15118 | 2/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | RECQL | P46063 | 1/20 | 0.64 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4408424 | 0.85 | MAPT (0.68) | HTTMAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL12417212 | 0.79 | MAPT (0.63) | HTTMAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL12417165 | 0.77 | MAPT (0.66) | HTTMAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL6721129 | 0.76 | MAPT (0.65) | HTTMAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL11913699 | 0.76 | MAPT (0.55) | HTTMAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL8239298 | 0.75 | KMT2A (0.60) | HTTMAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL8232019 | 0.74 | KMT2A (0.65) | HTTMAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL12443073 | 0.74 | KMT2A (0.74) | HTTMAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL12417160 | 0.73 | MAPT (0.60) | HTTMAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL14527790 | 0.72 | MAPT (0.54) | HTTMAPTKMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007051333-A1 | TRIAZINE BETA-SECRETASE INHIBITORS | ONCALIS AG (CH) | 2007-05-10 | — | — | WO | disclosed |