Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 6/20 | 0.64 |
| ▸ | CHRM2 | P08172 | 14/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12954737 | 0.86 | CCR5 (0.62) | CCR5CHRM2 | |
| SCHEMBL10073292 | 0.79 | CCR5 (1.00) | CCR5CHRM2 | |
| SCHEMBL22280457 | 0.77 | CCR5 (0.46) | CCR5CHRM2 | |
| SCHEMBL14529275 | 0.73 | CCR5 (0.62) | CCR5CHRM2 | |
| SCHEMBL12954809 | 0.72 | CCR5 (0.59) | CCR5CHRM2 | |
| SCHEMBL10084145 | 0.72 | CCR5 (0.73) | CCR5CHRM2 | |
| SCHEMBL28666871 | 0.68 | MC4R (0.49) | CCR5CHRM2 | |
| SCHEMBL28666869 | 0.68 | MC4R (0.49) | CCR5CHRM2 | |
| SCHEMBL28666867 | 0.68 | MC4R (0.49) | CCR5CHRM2 | |
| SCHEMBL4831671 | 0.68 | CCR5 (0.66) | CCR5CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007050375-A2 | PIPERAZINE DERIVATIVES USEFUL AS CCR5 ANTAGONISTS | SCHERING CORPORATION (US) | 2007-05-03 | — | — | WO | disclosed |