SCHEMBL14529640

SCHEMBL14529640

O=C(CCCCNCCc1ccccc1OC(F)(F)F)c1cc2c(c([SH](=O)=O)c1)CCC2

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B13 Q7Z5P4 1/20 0.36
DRD2 P14416 4/20 0.34
SLC6A3 Q01959 4/20 0.34
SLC2A1 P11166 2/20 0.34
PTGDR2 Q9Y5Y4 1/20 0.33
HDAC6 Q9UBN7 2/20 0.33
SCN9A Q15858 2/20 0.32
HDAC3 O15379 1/20 0.32
HDAC1 Q13547 1/20 0.32
HDAC2 Q92769 1/20 0.32
HTR2C P28335 1/20 0.32
HTR2B P41595 1/20 0.32
BCHE P06276 1/20 0.32
CHRM2 P08172 1/20 0.32
ACHE P22303 1/20 0.32
TRPV1 Q8NER1 2/20 0.32
CYP1A2 P05177 1/20 0.31
CYP2D6 P10635 1/20 0.31
CYP2C9 P11712 1/20 0.31
CYP2C19 P33261 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5308537 0.86 SLC2A1 (0.36) HSD17B13DRD2SLC6A3SLC2A1PTGDR2
Hydrochloric Acid SCHEMBL5308736 0.85 SLC2A1 (0.36) HSD17B13DRD2SLC6A3SLC2A1PTGDR2
SCHEMBL5577157 0.84 SLC2A1 (0.37) HSD17B13DRD2SLC6A3SLC2A1HDAC6
Hydrochloric Acid SCHEMBL5310762 0.84 SLC2A1 (0.36) HSD17B13DRD2SLC6A3SLC2A1HDAC6
SCHEMBL6034801 0.80 NPC1 (0.48) ACHE
Hydrochloric Acid SCHEMBL4850400 0.79 NPC1 (0.48) ACHE
SCHEMBL13987581 0.75 ALDH1A1 (0.44)
SCHEMBL6034260 0.75 HDAC6 (0.37) HSD17B13DRD2SLC6A3PTGDR2HDAC6
SCHEMBL5577106 0.74 PTGS1 (0.36) HSD17B13DRD2SLC6A3PTGDR2HDAC6
SCHEMBL5308103 0.74 PTGS1 (0.36) HSD17B13SLC2A1PTGDR2HDAC6HTR2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007052831-A1 PREVENTIVES/REMEDIES FOR URINARY DISTURBANCE TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-05-10 WO disclosed