Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 2/20 | 0.50 |
| ▸ | AURKA | O14965 | 6/20 | 0.44 |
| ▸ | MAPKAPK5 | Q8IW41 | 6/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14507206 | 0.90 | TTK (0.41) | TTKAURKAMAPKAPK5AURKBFYN | |
| SCHEMBL14530729 | 0.89 | AURKA (0.51) | TTKAURKAMAPKAPK5AURKBFYN | |
| SCHEMBL15146186 | 0.86 | FYN (0.49) | TTKAURKAMAPKAPK5AURKBFYN | |
| SCHEMBL14530725 | 0.84 | ABL1 (0.40) | TTKAURKAAURKB | |
| SCHEMBL14537080 | 0.81 | AURKA (0.45) | TTKAURKAMAPKAPK5AURKBFLT3 | |
| SCHEMBL14507243 | 0.80 | EGFR (0.41) | TTKAURKAMAPKAPK5AURKBFYN | |
| SCHEMBL14529891 | 0.78 | TTK (0.34) | TTKFLT3 | |
| SCHEMBL14530155 | 0.78 | AURKA (0.43) | TTKAURKAMAPKAPK5AURKBFLT3 | |
| SCHEMBL8247273 | 0.77 | AURKA (0.69) | TTKAURKAMAPKAPK5AURKBFYN | |
| SCHEMBL14530346 | 0.77 | HTT (0.41) | TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007058873-A2 | IMIDAZOPYRAZINES AS CYCLIN DEPENTEND KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-05-24 | — | — | WO | disclosed |