Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 8/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.45 |
| ▸ | FLT3 | P36888 | 6/20 | 0.35 |
| ▸ | TTK | P33981 | 3/20 | 0.33 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14529900 | 0.81 | TTK (0.50) | AURKAAURKBFLT3TTKMAPKAPK5 | |
| SCHEMBL14530155 | 0.79 | AURKA (0.43) | AURKAAURKBFLT3TTKMAPKAPK5 | |
| SCHEMBL14507206 | 0.79 | TTK (0.41) | AURKAAURKBFLT3TTKMAPKAPK5 | |
| SCHEMBL8240371 | 0.78 | AURKA (0.70) | AURKAAURKBFLT3TTKMAPKAPK5 | |
| SCHEMBL14530725 | 0.77 | ABL1 (0.40) | AURKAAURKBTTK | |
| SCHEMBL15146186 | 0.75 | FYN (0.49) | AURKAAURKBFLT3TTKMAPKAPK5 | |
| SCHEMBL12473053 | 0.75 | AURKB (0.54) | AURKAAURKBFLT3MAPKAPK5 | |
| SCHEMBL14530729 | 0.74 | AURKA (0.51) | AURKAAURKBTTKMAPKAPK5 | |
| SCHEMBL14536961 | 0.72 | FLT3 (0.51) | FLT3TTKADORA3 | |
| SCHEMBL15146139 | 0.72 | AURKB (0.49) | AURKAAURKBTTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007056468-A1 | METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION (US) | 2007-05-18 | — | — | WO | disclosed |