Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.54 |
| ▸ | AURKA | O14965 | 4/20 | 0.54 |
| ▸ | PTK6 | Q13882 | 5/20 | 0.49 |
| ▸ | LCK | P06239 | 3/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | CCND2 | P30279 | 1/20 | 0.39 |
| ▸ | CCND3 | P30281 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | TTK | P33981 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8245951 | 0.84 | AURKA (0.65) | MAPKAPK5AURKBAURKALCKSYK | |
| SCHEMBL14536960 | 0.80 | MAPKAPK5 (0.62) | MAPKAPK5AURKBAURKAPTK6LCK | |
| SCHEMBL30138985 | 0.80 | MAPKAPK5 (0.62) | MAPKAPK5AURKBAURKAPTK6LCK | |
| SCHEMBL12473561 | 0.80 | AURKA (0.70) | MAPKAPK5AURKBAURKAPTK6LCK | |
| SCHEMBL1674068 | 0.77 | MAPKAPK5 (0.62) | MAPKAPK5AURKBAURKAPTK6LCK | |
| SCHEMBL1674418 | 0.77 | MAPKAPK5 (0.73) | MAPKAPK5AURKBAURKAPTK6LCK | |
| SCHEMBL1674071 | 0.77 | MAPKAPK5 (0.70) | MAPKAPK5AURKBAURKAPTK6LCK | |
| SCHEMBL14530402 | 0.77 | MAPKAPK5 (0.58) | MAPKAPK5AURKBAURKAPTK6LCK | |
| SCHEMBL8246047 | 0.77 | FYN (0.52) | MAPKAPK5AURKBAURKAPTK6LCK | |
| SCHEMBL15063040 | 0.76 | MAPKAPK5 (0.69) | MAPKAPK5AURKBAURKAPTK6LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007058942-A2 | IMIDAZOPYRAZINES AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-05-24 | — | — | WO | disclosed |
| WO-2007058873-A2 | IMIDAZOPYRAZINES AS CYCLIN DEPENTEND KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-05-24 | — | — | WO | disclosed |