Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 15/20 | 0.45 |
| ▸ | AURKA | O14965 | 6/20 | 0.45 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.45 |
| ▸ | PTK6 | Q13882 | 3/20 | 0.44 |
| ▸ | LCK | P06239 | 4/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8240923 | 0.83 | AURKA (0.59) | AURKBAURKAPTK6CHEK1FLT3 | |
| SCHEMBL14537082 | 0.79 | AURKB (0.48) | AURKBAURKAMAPKAPK5PTK6LCK | |
| SCHEMBL30138985 | 0.75 | MAPKAPK5 (0.62) | AURKBAURKAMAPKAPK5PTK6LCK | |
| SCHEMBL12473048 | 0.74 | LCK (0.74) | AURKBAURKAPTK6LCKCHEK1 | |
| SCHEMBL8246047 | 0.74 | FYN (0.52) | AURKBAURKAMAPKAPK5PTK6LCK | |
| SCHEMBL14536960 | 0.73 | MAPKAPK5 (0.62) | AURKBAURKAMAPKAPK5PTK6LCK | |
| SCHEMBL14507803 | 0.72 | AURKB (0.68) | AURKBAURKAMAPKAPK5PTK6LCK | |
| SCHEMBL14536802 | 0.72 | PTK6 (0.54) | AURKBAURKAMAPKAPK5PTK6LCK | |
| SCHEMBL14530178 | 0.72 | AURKB (0.49) | AURKBAURKAMAPKAPK5PTK6LCK | |
| SCHEMBL14530726 | 0.71 | PTK6 (0.56) | AURKBAURKAMAPKAPK5PTK6LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007058873-A2 | IMIDAZOPYRAZINES AS CYCLIN DEPENTEND KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-05-24 | — | — | WO | disclosed |