Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.67 |
| ▸ | FLT3 | P36888 | 20/20 | 0.67 |
| ▸ | CDK2 | P24941 | 16/20 | 0.67 |
| ▸ | TYK2 | P29597 | 12/20 | 0.67 |
| ▸ | CCNA2 | P20248 | 11/20 | 0.67 |
| ▸ | CCNA1 | P78396 | 11/20 | 0.67 |
| ▸ | JAK1 | P23458 | 10/20 | 0.67 |
| ▸ | JAK3 | P52333 | 9/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.58 |
| ▸ | GAK | O14976 | 1/20 | 0.52 |
| ▸ | STK16 | O75716 | 1/20 | 0.52 |
| ▸ | STK10 | O94804 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | PRKCB | P05771 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | CSF1R | P07333 | 1/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | NQO2 | P16083 | 1/20 | 0.52 |
| ▸ | FER | P16591 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL824082 | 0.93 | JAK2 (0.69) | JAK2FLT3CDK2TYK2CCNA2 | |
| SCHEMBL824033 | 0.90 | JAK2 (0.68) | JAK2FLT3CDK2TYK2CCNA2 | |
| SCHEMBL824117 | 0.86 | FLT3 (0.68) | JAK2FLT3CDK2TYK2CCNA2 | |
| SCHEMBL14538460 | 0.85 | JAK2 (0.73) | JAK2FLT3CDK2TYK2CCNA2 | |
| SCHEMBL1108235 | 0.85 | JAK2 (0.79) | JAK2FLT3CDK2TYK2CCNA2 | |
| SCHEMBL823861 | 0.81 | JAK2 (0.79) | JAK2FLT3CDK2TYK2CCNA2 | |
| SCHEMBL1108222 | 0.81 | JAK2 (1.00) | JAK2FLT3CDK2TYK2CCNA2 | |
| SCHEMBL1108243 | 0.80 | JAK2 (0.74) | JAK2FLT3CDK2TYK2CCNA2 | |
| SCHEMBL823846 | 0.80 | JAK2 (1.00) | JAK2FLT3CDK2TYK2CCNA2 | |
| SCHEMBL1108233 | 0.79 | JAK2 (0.83) | JAK2FLT3CDK2TYK2CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007058628-A1 | HETEROALKYL LINKED PYRIMIDINE DERIVATIVES | S*BIO PTE LTD (SG) | 2007-05-24 | — | — | WO | disclosed |