Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 14/20 | 0.35 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.34 |
| ▸ | ACVRL1 | P37023 | 3/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.33 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.33 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.33 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14327055 | 0.88 | TYRO3 (0.39) | RIPK1 | |
| SCHEMBL14313053 | 0.88 | MERTK (0.39) | RIPK1TNK2DYRK3ROCK2MAPK1 | |
| SCHEMBL14313008 | 0.87 | TYRO3 (0.41) | RIPK1 | |
| SCHEMBL14898487 | 0.87 | MERTK (0.40) | RIPK1TNK2ACVRL1DYRK3ROCK2 | |
| SCHEMBL14312564 | 0.87 | BTK (0.39) | RIPK1ACVRL1DYRK3ROCK2MAPK1 | |
| SCHEMBL14312510 | 0.87 | AXL (0.35) | RIPK1TNK2ACVRL1IGF1RDYRK3 | |
| SCHEMBL14312623 | 0.87 | MERTK (0.36) | RIPK1TNK2ACVRL1IGF1RDYRK3 | |
| SCHEMBL14312579 | 0.86 | ACVRL1 (0.45) | RIPK1TNK2ACVRL1IGF1R | |
| SCHEMBL14327087 | 0.86 | TYRO3 (0.43) | RIPK1ACVRL1IGF1RDYRK3ROCK2 | |
| SCHEMBL14312523 | 0.86 | PIK3CD (0.40) | RIPK1ACVRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007056170-A2 | PYRROLO[2,1-F] [1,2,4] TRIAZIN-4-YLAMINES IGF-1R KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER HYPERPROLIFERATIVE DISEASES | BAYER HEALTHCARE AG (DE) | 2007-05-18 | — | — | WO | disclosed |