Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVRL1 | P37023 | 6/20 | 0.45 |
| ▸ | TYRO3 | Q06418 | 13/20 | 0.43 |
| ▸ | AXL | P30530 | 3/20 | 0.43 |
| ▸ | MERTK | Q12866 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14898503 | 0.91 | TYRO3 (0.51) | ACVRL1TYRO3AXLMERTK | |
| SCHEMBL14327071 | 0.85 | TYRO3 (0.44) | ACVRL1TYRO3AXLMERTK | |
| SCHEMBL5077162 | 0.85 | ACVRL1 (0.46) | ACVRL1TYRO3AXLMERTK | |
| SCHEMBL5077435 | 0.83 | ACVRL1 (0.56) | ACVRL1TYRO3 | |
| SCHEMBL14327121 | 0.81 | MERTK (0.45) | ACVRL1TYRO3AXLMERTK | |
| SCHEMBL14888107 | 0.80 | TYRO3 (0.49) | TYRO3AXLMERTK | |
| SCHEMBL14312766 | 0.79 | TYRO3 (0.54) | ACVRL1TYRO3AXLMERTK | |
| SCHEMBL14312618 | 0.78 | TYRO3 (0.48) | ACVRL1TYRO3AXLMERTK | |
| SCHEMBL14531340 | 0.77 | TYRO3 (0.38) | ACVRL1TYRO3AXLMERTK | |
| SCHEMBL14312707 | 0.77 | TYRO3 (0.52) | ACVRL1TYRO3AXLMERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007056170-A2 | PYRROLO[2,1-F] [1,2,4] TRIAZIN-4-YLAMINES IGF-1R KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER HYPERPROLIFERATIVE DISEASES | BAYER HEALTHCARE AG (DE) | 2007-05-18 | — | — | WO | disclosed |