Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 6/20 | 0.42 |
| ▸ | DYRK2 | Q92630 | 6/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 6/20 | 0.42 |
| ▸ | DYRK3 | O43781 | 5/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1761767 | 0.81 | KDM4E (0.45) | MAPTTP53SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL12834509 | 0.80 | HDAC6 (0.44) | MAPTKDM4EHDAC6HDAC3HDAC1 | |
| SCHEMBL12834422 | 0.80 | HDAC6 (0.44) | MAPTKDM4EHDAC6HDAC3HDAC1 | |
| SCHEMBL12833979 | 0.76 | HDAC6 (0.44) | MAPTKDM4EHDAC6HDAC3HDAC1 | |
| SCHEMBL14531805 | 0.74 | HDAC6 (0.42) | MAPTKDM4EHDAC6HDAC3HDAC1 | |
| SCHEMBL14090471 | 0.74 | HDAC6 (0.47) | CCNA2CDK2IKBKBHDAC6HDAC3 | |
| SCHEMBL12833922 | 0.73 | HDAC6 (0.42) | MAPTSMN1; SMN2KDM4ENPC1RAB9A | |
| SCHEMBL12833860 | 0.73 | HDAC6 (0.42) | KDM4EHDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL12833859 | 0.72 | ROCK2 (0.48) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL12834063 | 0.71 | HDAC6 (0.40) | KDM4EHDAC6HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007056155-A1 | HETEROCYCLIC COMPOUNDS AS TYROSINE KINASE MODULATORS | CHEMBRIDGE RESEARCH LABORATORIES, INC. (US) | 2007-05-18 | — | — | WO | disclosed |