Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.42 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | RHEB | Q15382 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14091505 | 0.79 | KDM4E (0.60) | BRD4MMP2MMP9MMP8MMP13 | |
| SCHEMBL14091523 | 0.78 | NR4A2 (0.53) | BRD4MMP2MMP9MMP8MMP13 | |
| SCHEMBL20982471 | 0.70 | MMP2 (0.78) | BRD4MMP2MMP9MMP8MMP13 | |
| SCHEMBL12834035 | 0.68 | KDM4E (0.73) | BRD4MMP2MMP9MMP8MMP13 | |
| SCHEMBL2617479 | 0.67 | KDM4E (0.71) | BRD4MMP2MMP9MMP8MMP13 | |
| SCHEMBL19763371 | 0.66 | CHEK2 (0.72) | BRD4MMP2MMP9MMP8MMP13 | |
| SCHEMBL5222037 | 0.66 | MMP2 (0.75) | MMP2MMP9MMP8MMP13KDM4E | |
| SCHEMBL32660766 | 0.66 | F2 (0.65) | KDM4EALDH1A1LMNAL3MBTL1NPC1 | |
| SCHEMBL19982677 | 0.66 | F2 (0.65) | KDM4EALDH1A1LMNAL3MBTL1NPC1 | |
| SCHEMBL14091482 | 0.66 | BRD4 (0.52) | BRD4MMP2MMP9MMP8MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007056155-A1 | HETEROCYCLIC COMPOUNDS AS TYROSINE KINASE MODULATORS | CHEMBRIDGE RESEARCH LABORATORIES, INC. (US) | 2007-05-18 | — | — | WO | disclosed |