Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 10/20 | 0.52 |
| ▸ | CDK2 | P24941 | 10/20 | 0.52 |
| ▸ | CCNA1 | P78396 | 10/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.47 |
| ▸ | PIK3R2 | O00459 | 3/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.47 |
| ▸ | PIK3R5 | Q8WYR1 | 3/20 | 0.47 |
| ▸ | PIK3R3 | Q92569 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 3/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14502642 | 0.88 | CCNA2 (0.53) | CCNA2CDK2CCNA1PIK3CDPIK3R2 | |
| SCHEMBL5255628 | 0.86 | CCNA2 (0.54) | CCNA2CDK2CCNA1IKBKB | |
| SCHEMBL14532847 | 0.84 | ALDH1A1 (0.55) | CCNA2CDK2CCNA1PIK3CDPIK3R2 | |
| SCHEMBL5255911 | 0.83 | CCNA2 (0.46) | CCNA2CDK2CCNA1PIK3CDPIK3R2 | |
| SCHEMBL14502646 | 0.83 | PIK3CD (0.51) | CCNA2CDK2CCNA1PIK3CDPIK3R2 | |
| SCHEMBL5254406 | 0.79 | IKBKB (0.60) | IKBKB | |
| SCHEMBL5254000 | 0.78 | IKBKB (0.55) | CCNA2CDK2CCNA1IKBKB | |
| SCHEMBL9832871 | 0.77 | PTGS1 (0.49) | CCNA2CDK2CCNA1PIK3CDPIK3R2 | |
| SCHEMBL5257991 | 0.76 | IKBKB (0.55) | CCNA2CDK2CCNA1IKBKB | |
| SCHEMBL5254936 | 0.76 | IKBKB (0.76) | IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7211597-B2 | Substituted pyrazolyl compounds for the treatment of inflammation | PHARMACIA CORPORATION | 2007-05-01 | — | — | US | disclosed |