Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | BUB1 | O43683 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4340498 | 0.90 | KDM4E (0.47) | KDM4EALDH1A1HPGDHSD17B10KMT2A | |
| SCHEMBL4346852 | 0.82 | KDM4E (0.45) | KDM4EALDH1A1HPGDHSD17B10KMT2A | |
| SCHEMBL4334691 | 0.78 | KDM4E (0.52) | KDM4EALDH1A1HPGDHSD17B10KMT2A | |
| SCHEMBL4338517 | 0.77 | BUB1 (0.41) | KDM4EALDH1A1HPGDBUB1MEN1 | |
| SCHEMBL4332934 | 0.77 | KDM4E (0.52) | KDM4EALDH1A1HPGDHSD17B10KMT2A | |
| SCHEMBL4339459 | 0.77 | KDM4E (0.47) | KDM4EALDH1A1HPGDHSD17B10MAPK1 | |
| SCHEMBL4351579 | 0.76 | KDM4E (0.43) | KDM4EALDH1A1HPGDHSD17B10MAPK1 | |
| SCHEMBL4340512 | 0.75 | KDM4E (0.65) | KDM4EALDH1A1HPGDHSD17B10KMT2A | |
| SCHEMBL4332758 | 0.73 | MEN1 (0.57) | KDM4EALDH1A1HPGDBUB1HSD17B10 | |
| SCHEMBL4334984 | 0.73 | KDM4E (0.48) | KDM4EALDH1A1HPGDHSD17B10KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501796-B1 | 3-(PYRIDINYL-AMINO)-1H-INDOLE-2-CARBOXYLIC ACID DERIVATIVES AS INTERLEUKIN-4 GENE EXPRESSION INHIBITORS | AVENTIS PHARMA INC (US) | 2007-05-09 | — | — | EP | disclosed |