Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BUB1 | O43683 | 10/20 | 0.41 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.39 |
| ▸ | GABRE | P78334 | 1/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.39 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.39 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.39 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4347024 | 0.84 | KDM4E (0.47) | KDM4EMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL4344246 | 0.83 | POLB (0.37) | BUB1POLBIMPDH2MAPKAPK2KDM4E | |
| SCHEMBL4342779 | 0.83 | MAPKAPK2 (0.37) | BUB1MAPKAPK2 | |
| SCHEMBL4340498 | 0.79 | KDM4E (0.47) | KDM4EKMT2AALDH1A1HPGD | |
| SCHEMBL14534367 | 0.77 | KDM4E (0.39) | BUB1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL4337467 | 0.75 | MCL1 (0.41) | BUB1KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL4346788 | 0.72 | MMP2 (0.41) | BUB1POLBIMPDH2KDM4EMEN1 | |
| SCHEMBL4332758 | 0.71 | MEN1 (0.57) | BUB1POLBKDM4EMEN1KMT2A | |
| SCHEMBL4334975 | 0.70 | MAPT (0.45) | KDM4EMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL4346852 | 0.70 | KDM4E (0.45) | KDM4EKMT2AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501797-B1 | 3-(SUBSTITUTED AMINO)-1H-INDOLE-2-CARBOXYLIC ACID ESTER AND 3-(SUBSTITUTED AMINO)-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID ESTER DERIVATIVES AS INTERLEUKIN-4 GENE EXPRESSION INHIBITORS | AVENTIS PHARMA INC (US) | 2009-08-05 | — | — | EP | claimed |