Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.57 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 4/20 | 0.53 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14535523 | 0.90 | MAPT (0.58) | SMN1; SMN2POLBMAPTACKR3CHRM1 | |
| SCHEMBL1075259 | 0.88 | ACKR3 (0.73) | SMN1; SMN2POLBMAPTACKR3CHRM1 | |
| SCHEMBL13069467 | 0.87 | ACKR3 (0.56) | SMN1; SMN2POLBMAPTACKR3CHRM1 | |
| SCHEMBL13068971 | 0.86 | ACKR3 (0.57) | SMN1; SMN2POLBMAPTACKR3LMNA | |
| SCHEMBL14535521 | 0.86 | ACKR3 (0.57) | SMN1; SMN2POLBMAPTACKR3LMNA | |
| SCHEMBL12707269 | 0.85 | ACKR3 (0.56) | SMN1; SMN2POLBMAPTACKR3LMNA | |
| SCHEMBL13068963 | 0.85 | ACKR3 (0.56) | SMN1; SMN2POLBMAPTACKR3TP53 | |
| SCHEMBL13069581 | 0.85 | ACKR3 (0.55) | SMN1; SMN2POLBMAPTACKR3LMNA | |
| SCHEMBL12707248 | 0.84 | ACKR3 (0.79) | SMN1; SMN2POLBMAPTACKR3TP53 | |
| SCHEMBL14535570 | 0.83 | ACKR3 (0.58) | SMN1; SMN2POLBMAPTACKR3CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007059108-A2 | SUBSTITUTED QUINOLONES AND METHODS OF USE | CHEMOCENTRYX, INC. (US) | 2007-05-24 | — | — | WO | disclosed |