Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 4/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14535532 | 0.90 | SMN1; SMN2 (0.59) | MAPTACKR3SMN1; SMN2POLBLMNA | |
| SCHEMBL1072679 | 0.89 | ACKR3 (0.73) | MAPTACKR3SMN1; SMN2POLBLMNA | |
| SCHEMBL14535577 | 0.86 | ACKR3 (0.59) | MAPTACKR3SMN1; SMN2POLBLMNA | |
| SCHEMBL13068963 | 0.85 | ACKR3 (0.56) | MAPTACKR3SMN1; SMN2POLBTP53 | |
| SCHEMBL12707248 | 0.85 | ACKR3 (0.79) | MAPTACKR3SMN1; SMN2POLBTP53 | |
| SCHEMBL13069467 | 0.83 | ACKR3 (0.56) | MAPTACKR3SMN1; SMN2POLBLMNA | |
| SCHEMBL14535570 | 0.83 | ACKR3 (0.58) | MAPTACKR3SMN1; SMN2POLBLMNA | |
| SCHEMBL12707164 | 0.81 | ACKR3 (0.62) | MAPTACKR3SMN1; SMN2POLBLMNA | |
| SCHEMBL12707261 | 0.81 | ACKR3 (0.58) | MAPTACKR3SMN1; SMN2POLBLMNA | |
| SCHEMBL13068971 | 0.81 | ACKR3 (0.57) | MAPTACKR3SMN1; SMN2POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007059108-A2 | SUBSTITUTED QUINOLONES AND METHODS OF USE | CHEMOCENTRYX, INC. (US) | 2007-05-24 | — | — | WO | disclosed |