Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1072510 | 0.89 | TSHR (0.49) | TSHRMAPK1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL14535531 | 0.88 | TSHR (0.57) | TSHRMAPK1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL2962023 | 0.76 | TDP1 (0.46) | TSHRMAPK1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL1022198 | 0.76 | TSHR (0.59) | TSHRMAPK1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL13069024 | 0.76 | LMNA (0.64) | TSHRMAPK1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL1072203 | 0.73 | ACKR3 (0.42) | TSHRMAPK1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL1073496 | 0.73 | KMT2A (0.45) | TSHRMAPK1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL1072550 | 0.72 | LMNA (0.48) | TSHRMAPK1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL11789908 | 0.71 | SMN1; SMN2 (0.79) | TSHRMAPK1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL12707220 | 0.70 | MAPT (0.59) | LMNATDP1MAPTRXFP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007059108-A2 | SUBSTITUTED QUINOLONES AND METHODS OF USE | CHEMOCENTRYX, INC. (US) | 2007-05-24 | — | — | WO | disclosed |