Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 4/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.41 |
| ▸ | AXL | P30530 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL266257 | 0.85 | SYK (0.48) | ROCK1JAK2JAK1TYK2JAK3 | |
| SCHEMBL264663 | 0.85 | JAK2 (0.42) | ROCK1JAK2JAK1TYK2JAK3 | |
| SCHEMBL270515 | 0.83 | SYK (0.51) | JAK2JAK1JAK3IKBKBSYK | |
| Hydrochloric Acid SCHEMBL263896 | 0.82 | SYK (0.50) | JAK2JAK1JAK3IKBKBSYK | |
| SCHEMBL264522 | 0.81 | CAMK2D (0.48) | JAK2JAK1TYK2JAK3AXL | |
| SCHEMBL270503 | 0.81 | JAK2 (0.56) | JAK2JAK1JAK3SYKTYRO3 | |
| SCHEMBL266088 | 0.80 | BRD4 (0.56) | TYRO3AXLAURKAPDGFRBPDGFRA | |
| SCHEMBL270122 | 0.79 | AXL (0.46) | JAK2JAK1TYK2JAK3SYK | |
| SCHEMBL265568 | 0.79 | SOS1 (0.45) | JAK2JAK1TYK2JAK3SYK | |
| Hydrochloric Acid SCHEMBL266775 | 0.78 | AXL (0.46) | JAK2JAK1TYK2JAK3SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007053452-A1 | BI-ARYL META-PYRIMIDINE INHIBITORS OF KINASES | TARGEGEN, INC. (US) | 2007-05-10 | — | — | WO | disclosed |