Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK6 | Q13882 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 16/20 | 0.35 |
| ▸ | AURKA | O14965 | 13/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.35 |
| ▸ | TTK | P33981 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | YES1 | P07947 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12471059 | 0.87 | PTK6 (0.40) | PTK6AURKBAURKAAXLTYRO3 | |
| SCHEMBL14536799 | 0.79 | AURKB (0.49) | PTK6AURKBAURKAAXLTYRO3 | |
| SCHEMBL12471160 | 0.72 | AURKB (0.58) | AURKBAURKACHEK1LCKKDR | |
| SCHEMBL12473591 | 0.69 | AURKB (0.59) | AURKBAURKACHEK1LCKKDR | |
| SCHEMBL8239782 | 0.69 | AURKA (0.65) | PTK6AURKBAURKAAXLTYRO3 | |
| SCHEMBL8246885 | 0.65 | AURKB (0.65) | AURKBAURKACHEK1LCKKDR | |
| SCHEMBL14536779 | 0.64 | AURKB (0.44) | PTK6AURKBAURKACHEK1LCK | |
| SCHEMBL14507591 | 0.64 | ANPEP (0.41) | PTK6AURKBAURKATTKNTRK1 | |
| SCHEMBL12404465 | 0.63 | AURKA (0.67) | AURKBAURKACHEK1LCKKDR | |
| SCHEMBL14536767 | 0.63 | TTK (0.40) | PTK6AURKBAURKACHEK1TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007056468-A1 | METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION (US) | 2007-05-18 | — | — | WO | disclosed |