Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 17/20 | 0.59 |
| ▸ | IGF1R | P08069 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19264256 | 0.90 | TNK2 (0.59) | TNK2IGF1R | |
| SCHEMBL4541532 | 0.86 | TNK2 (0.58) | TNK2IGF1RCYP3A4 | |
| SCHEMBL401216 | 0.86 | TNK2 (0.58) | TNK2IGF1RCYP3A4 | |
| SCHEMBL10226172 | 0.86 | TNK2 (0.58) | TNK2IGF1RCYP3A4 | |
| SCHEMBL19264081 | 0.85 | TNK2 (0.57) | TNK2IGF1R | |
| SCHEMBL19264180 | 0.84 | TNK2 (0.46) | TNK2IGF1RCYP3A4 | |
| SCHEMBL2797385 | 0.80 | TNK2 (0.52) | TNK2IGF1R | |
| SCHEMBL14536941 | 0.79 | TNK2 (0.59) | TNK2IGF1R | |
| SCHEMBL19264070 | 0.76 | TNK2 (0.63) | TNK2IGF1RCYP3A4 | |
| SCHEMBL14536746 | 0.75 | TNK2 (0.57) | TNK2IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168968-B1 | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors | OSI PHARMACEUTICALS LLC (US) | 2017-08-23 | — | — | EP | disclosed |
| WO-2007061737-A2 | FUSED BICYCLIC mTOR INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2007-05-31 | — | — | WO | disclosed |