Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 15/20 | 0.57 |
| ▸ | IGF1R | P08069 | 5/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | INSR | P06213 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19264256 | 0.85 | TNK2 (0.59) | TNK2IGF1RPDPK1ABL1EGFR | |
| SCHEMBL402054 | 0.83 | TNK2 (0.59) | TNK2IGF1RPDPK1ABL1EGFR | |
| SCHEMBL401909 | 0.83 | TNK2 (0.59) | TNK2IGF1RPDPK1ABL1EGFR | |
| SCHEMBL14536933 | 0.80 | TNK2 (0.59) | TNK2IGF1RINSRKDRMAP2K1 | |
| SCHEMBL1567075 | 0.77 | TNK2 (0.53) | TNK2IGF1R | |
| SCHEMBL14536736 | 0.75 | TNK2 (0.59) | TNK2IGF1R | |
| SCHEMBL14536737 | 0.74 | TNK2 (0.59) | TNK2IGF1R | |
| SCHEMBL13812328 | 0.74 | TNK2 (0.48) | TNK2IGF1RPDPK1ABL1EGFR | |
| SCHEMBL19264027 | 0.73 | TNK2 (0.46) | TNK2IGF1RPDPK1ABL1EGFR | |
| SCHEMBL13772613 | 0.73 | TNK2 (0.69) | TNK2IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007061737-A2 | FUSED BICYCLIC mTOR INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2007-05-31 | — | — | WO | disclosed |