Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.59 |
| ▸ | LCK | P06239 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 14/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 14/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.43 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.43 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8246944 | 0.86 | CHEK1 (0.77) | CHEK1LCKAURKAAURKBEGFR | |
| SCHEMBL14530381 | 0.79 | AURKA (0.56) | CHEK1LCKAURKAAURKBEGFR | |
| SCHEMBL14529949 | 0.79 | LCK (0.49) | CHEK1LCKAURKAAURKBEGFR | |
| SCHEMBL14537052 | 0.78 | LCK (0.49) | CHEK1LCKAURKAAURKBEGFR | |
| SCHEMBL14537050 | 0.77 | AURKB (0.55) | CHEK1LCKAURKAAURKBEGFR | |
| SCHEMBL14538375 | 0.77 | CHEK1 (0.49) | CHEK1LCKAURKAAURKBEGFR | |
| SCHEMBL8241428 | 0.74 | CHEK1 (1.00) | CHEK1LCKAURKAAURKBEGFR | |
| SCHEMBL13955025 | 0.72 | CHEK1 (0.78) | CHEK1LCKAURKAAURKBEGFR | |
| SCHEMBL14536996 | 0.70 | CHEK1 (0.75) | CHEK1LCKAURKAAURKBEGFR | |
| SCHEMBL12404504 | 0.70 | CHEK1 (0.74) | CHEK1LCKAURKAAURKBEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007056468-A1 | METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION (US) | 2007-05-18 | — | — | WO | disclosed |