Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 6/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.40 |
| ▸ | FLT3 | P36888 | 2/20 | 0.37 |
| ▸ | TTK | P33981 | 11/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14536951 | 0.90 | AURKA (0.37) | AURKAAURKBFLT3TTK | |
| SCHEMBL8240298 | 0.86 | AURKA (0.50) | AURKAAURKBFLT3TTK | |
| SCHEMBL14537078 | 0.70 | ADORA3 (0.46) | AURKAAURKBFLT3TTK | |
| SCHEMBL8427934 | 0.69 | ADORA3 (0.37) | FLT3 | |
| SCHEMBL5394350 | 0.68 | TTK (0.55) | FLT3TTK | |
| SCHEMBL8241176 | 0.68 | AURKA (0.58) | AURKAAURKBTTK | |
| SCHEMBL8240135 | 0.67 | AURKA (0.58) | AURKAAURKBFLT3TTK | |
| SCHEMBL5403454 | 0.67 | FLT3 (0.51) | FLT3TTK | |
| SCHEMBL14537009 | 0.67 | FLT3 (0.46) | AURKAAURKBFLT3TTK | |
| SCHEMBL8247827 | 0.66 | AURKA (0.53) | AURKAAURKBTTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007056468-A1 | METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION (US) | 2007-05-18 | — | — | WO | disclosed |