Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK2 | Q16620 | 4/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.34 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.30 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13885180 | 0.80 | NTRK2 (0.83) | NTRK2NTRK1EGFRERBB2ERBB3 | |
| SCHEMBL12537616 | 0.79 | NTRK1 (0.68) | NTRK2NTRK1EGFRERBB2ERBB3 | |
| SCHEMBL1924640 | 0.71 | NTRK2 (1.00) | NTRK2NTRK1EGFRERBB2ERBB3 | |
| SCHEMBL1925304 | 0.71 | NTRK2 (0.79) | NTRK2NTRK1EGFRERBB2ERBB3 | |
| SCHEMBL12537229 | 0.68 | NTRK2 (0.71) | NTRK2NTRK1EGFRERBB2ERBB3 | |
| SCHEMBL1926089 | 0.67 | NTRK2 (0.72) | NTRK2NTRK1EGFRERBB2ERBB3 | |
| SCHEMBL12537482 | 0.67 | NTRK2 (0.53) | NTRK2NTRK1LMNANPC1POLB | |
| SCHEMBL13885220 | 0.67 | NTRK2 (0.74) | NTRK2NTRK1EGFRERBB2ERBB3 | |
| SCHEMBL1925284 | 0.67 | NTRK2 (0.74) | NTRK2NTRK1EGFRERBB2ERBB3 | |
| SCHEMBL1925817 | 0.67 | NTRK1 (0.59) | NTRK2NTRK1EGFRERBB2ERBB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007061882-A2 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-05-31 | — | — | WO | disclosed |