Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 20/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12795739 | 0.92 | P2RX7 (0.73) | P2RX7 | |
| SCHEMBL14225237 | 0.85 | P2RX7 (0.70) | P2RX7 | |
| SCHEMBL12795681 | 0.80 | P2RX7 (0.68) | P2RX7 | |
| SCHEMBL13985055 | 0.78 | P2RX7 (0.82) | P2RX7 | |
| SCHEMBL14225217 | 0.78 | P2RX7 (0.81) | P2RX7 | |
| SCHEMBL12795761 | 0.78 | P2RX7 (0.88) | P2RX7 | |
| SCHEMBL12795852 | 0.77 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL12795758 | 0.77 | P2RX7 (0.72) | P2RX7 | |
| SCHEMBL12795779 | 0.77 | P2RX7 (0.79) | P2RX7 | |
| SCHEMBL12795782 | 0.75 | P2RX7 (0.76) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8349858-B2 | Polycyclic guanine derivatives and use thereof | MERCK SHARP & DOHME (US) | 2013-01-08 | — | — | US | disclosed |
| US-8349858-B2 | Polycyclic guanine derivatives and use thereof | MERCK SHARP & DOHME (US) | 2013-01-08 | — | — | US | disclosed |