Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | TYMS | P04818 | 1/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.33 |
| ▸ | TUBB | P07437 | 2/20 | 0.33 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.33 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.33 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.33 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.33 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.33 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.33 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.33 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.33 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.33 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.33 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.33 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.33 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.33 |
| ▸ | PNP | P00491 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14537585 | 0.86 | TOP2A (0.37) | MAPTTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL14537594 | 0.85 | MAPT (0.45) | MAPTDHFRTYMSTUBB4ATUBB | |
| SCHEMBL14537593 | 0.83 | MAPT (0.46) | MAPTDHFRTYMSICAM1SELE | |
| SCHEMBL14537589 | 0.80 | MAPT (0.46) | MAPTDHFRTYMSTUBB4ATUBB | |
| SCHEMBL14537592 | 0.80 | MAPT (0.43) | MAPTDHFRTYMSTUBB4ATUBB | |
| SCHEMBL14537573 | 0.78 | MAPT (0.66) | MAPTTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL14537587 | 0.77 | MAPT (0.46) | MAPTDHFRTYMSTUBB4ATUBB | |
| SCHEMBL14537591 | 0.76 | MAPT (0.42) | MAPTDHFRTYMS | |
| SCHEMBL14537590 | 0.75 | MAPT (0.43) | MAPTDHFRTYMS | |
| SCHEMBL14537586 | 0.73 | CYP3A4 (0.50) | MAPTPTGDR2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8349867-B2 | Quinoline compounds, intermediates, preparation methods and uses thereof | SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY (CN) | 2013-01-08 | — | — | US | disclosed |