Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | ATM | Q13315 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.47 |
| ▸ | TUBB | P07437 | 2/20 | 0.47 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.47 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.47 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.47 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14537572 | 0.88 | MAPT (0.71) | MAPTALDH1A1NPSR1ATMSMN1; SMN2 | |
| SCHEMBL14537571 | 0.86 | MAPT (0.76) | MAPTALDH1A1NPSR1ATMSMN1; SMN2 | |
| SCHEMBL14537567 | 0.84 | MAPT (0.70) | MAPTALDH1A1NPSR1ATMSMN1; SMN2 | |
| SCHEMBL14537570 | 0.84 | MAPT (0.69) | MAPTALDH1A1NPSR1ATMSMN1; SMN2 | |
| SCHEMBL14537564 | 0.81 | MAPT (0.79) | MAPTALDH1A1NPSR1ATMSMN1; SMN2 | |
| SCHEMBL14537569 | 0.81 | MAPT (0.70) | MAPTALDH1A1NPSR1ATMSMN1; SMN2 | |
| SCHEMBL14537568 | 0.80 | MAPT (0.72) | MAPTALDH1A1NPSR1ATMSMN1; SMN2 | |
| SCHEMBL14537595 | 0.78 | MAPT (0.38) | MAPTPOLBTDP1TUBB4ATUBB | |
| SCHEMBL14537565 | 0.78 | MAPT (0.70) | MAPTALDH1A1NPSR1ATMSMN1; SMN2 | |
| SCHEMBL14537566 | 0.75 | MAPT (0.69) | MAPTALDH1A1NPSR1ATMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8349867-B2 | Quinoline compounds, intermediates, preparation methods and uses thereof | SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY (CN) | 2013-01-08 | — | — | US | disclosed |