Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTRL | P40313 | 12/20 | 0.82 |
| ▸ | TMPRSS11D | O60235 | 5/20 | 0.82 |
| ▸ | PSMB5 | P28074 | 8/20 | 0.59 |
| ▸ | PSMB11 | A5LHX3 | 2/20 | 0.59 |
| ▸ | PSMA7 | O14818 | 2/20 | 0.59 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.59 |
| ▸ | PSMA1 | P25786 | 2/20 | 0.59 |
| ▸ | PSMA2 | P25787 | 2/20 | 0.59 |
| ▸ | PSMA3 | P25788 | 2/20 | 0.59 |
| ▸ | PSMA4 | P25789 | 2/20 | 0.59 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.59 |
| ▸ | PSMB9 | P28065 | 2/20 | 0.59 |
| ▸ | PSMA5 | P28066 | 2/20 | 0.59 |
| ▸ | PSMB4 | P28070 | 2/20 | 0.59 |
| ▸ | PSMB6 | P28072 | 2/20 | 0.59 |
| ▸ | PSMB10 | P40306 | 2/20 | 0.59 |
| ▸ | PSMB3 | P49720 | 2/20 | 0.59 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.59 |
| ▸ | PSMA6 | P60900 | 2/20 | 0.59 |
| ▸ | PSMA8 | Q8TAA3 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19289278 | 1.00 | CTRL (0.82) | CTRLTMPRSS11DPSMB5PSMB11PSMA7 | |
| SCHEMBL8134932 | 1.00 | CTRL (0.82) | CTRLTMPRSS11DPSMB5PSMB11PSMA7 | |
| SCHEMBL19289575 | 0.94 | CTRL (0.92) | CTRLTMPRSS11DPSMB5PSMB11PSMA7 | |
| SCHEMBL19341750 | 0.94 | CTRL (0.92) | CTRLTMPRSS11DPSMB5PSMB11PSMA7 | |
| SCHEMBL8135090 | 0.94 | CTRL (0.92) | CTRLTMPRSS11DPSMB5PSMB11PSMA7 | |
| SCHEMBL14538228 | 0.94 | CTRL (0.92) | CTRLTMPRSS11DPSMB5PSMB11PSMA7 | |
| SCHEMBL8123039 | 0.94 | CTRL (0.90) | CTRLTMPRSS11DPSMB5PSMB11PSMA7 | |
| SCHEMBL22423754 | 0.94 | CTRL (0.90) | CTRLTMPRSS11DPSMB5PSMB11PSMA7 | |
| SCHEMBL8135868 | 0.94 | CTRL (0.90) | CTRLTMPRSS11DPSMB5PSMB11PSMA7 | |
| SCHEMBL19289605 | 0.94 | CTRL (0.90) | CTRLTMPRSS11DPSMB5PSMB11PSMA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170260230-A1 | COMPUNDS FOR ENZYME INHIBITION | ONYX THERAPEUTICS INC (US) | 2017-09-14 | — | — | US | disclosed |
| EP-3021862-B1 | PEPTIDE EPOXYKETONE PROTEASOME INHIBITORS IN COMBINATION WITH PIM KINASE INHIBITORS FOR TREATMENT OF CANCERS | ONYX THERAPEUTICS INC (US) | 2017-08-30 | — | — | EP | disclosed |
| US-20160166632-A1 | PEPTIDE EPOXYKETONE PROTEASOME INHIBITORS IN COMBINATION WITH PIM KINASE INHIBITORS FOR TREATMENT OF CANCERS | ONYX THERAPEUTICS INC (US) | 2016-06-16 | — | — | US | disclosed |
| US-20160083421-A1 | COMPUNDS FOR ENZYME INHIBITION | ONYX THERAPEUTICS INC (US) | 2016-03-24 | — | — | US | disclosed |
| US-9205125-B2 | Compounds for enzyme inhibition | ONYX THERAPEUTICS, INC. (US) | 2015-12-08 | — | — | US | disclosed |
| US-9205126-B2 | Compounds for enzyme inhibition | ONYX THERAPEUTICS, INC. (US) | 2015-12-08 | — | — | US | disclosed |
| US-9205124-B2 | Compounds for enzyme inhibition | ONYX THERAPEUTICS, INC. (US) | 2015-12-08 | — | — | US | disclosed |
| WO-2015009888-A2 | PEPTIDE EPOXYKETONE PROTEASOME INHIBITORS IN COMBINATION WITH PIM KINASE INHIBITORS FOR TREATMENT OF CANCERS | ONYX THERAPEUTICS, INC. (US) | 2015-01-22 | — | — | WO | disclosed |
| US-8716322-B2 | Compounds for enzyme inhibition | ONYX THERAPEUTICS, INC. (US) | 2014-05-06 | — | — | US | disclosed |
| US-20140050737-A1 | COMPOUNDS FOR ENZYME INHIBITION | ONYX THERAPEUTICS, INC. (US) | 2014-02-20 | — | — | US | disclosed |
| US-20140031297-A1 | COMPOUNDS FOR ENZYME INHIBITION | ONYX THERAPEUTICS, INC. (US) | 2014-01-30 | — | — | US | disclosed |
| US-20130130968-A1 | COMPOUNDS FOR ENZYME INHIBITION | ONYX THERAPEUTICS, INC. (US) | 2013-05-23 | — | — | US | disclosed |
| WO-2007056464-A1 | COMPOUNDS FOR ENZYME INHIBITION | PROTEOLIX, INC. (US) | 2007-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130130968-A1 | COMPOUNDS FOR ENZYME INHIBITION | ANPEP, HPN, DNPEP | CTRL 27/4885TMPRSS11D 311/4885PSMB5 19/4885 |
| US-20160166632-A1 | PEPTIDE EPOXYKETONE PROTEASOME INHIBITORS IN COMBINATION WITH PIM KINASE INHIBITORS FOR TREATMENT OF CANCERS | PIM1, PIM2, PIM3 | CTRL 1320/4885TMPRSS11D 500/4885PSMB5 57/4885 |
| US-20170260230-A1 | COMPUNDS FOR ENZYME INHIBITION | ANPEP, PSMB1, CPN1 | CTRL 26/4885TMPRSS11D 307/4885PSMB5 25/4885 |
| US-20140050737-A1 | COMPOUNDS FOR ENZYME INHIBITION | ANPEP, HPN, DNPEP | CTRL 27/4885TMPRSS11D 311/4885PSMB5 19/4885 |
| US-20140031297-A1 | COMPOUNDS FOR ENZYME INHIBITION | ANPEP, HPN, DNPEP | CTRL 27/4885TMPRSS11D 311/4885PSMB5 19/4885 |
| US-20160083421-A1 | COMPUNDS FOR ENZYME INHIBITION | ANPEP, PSMB1, CPN1 | CTRL 26/4885TMPRSS11D 307/4885PSMB5 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.