SCHEMBL14539722 — predicted protein targets

Predicted protein targets (top 15)

	gene	UniProt	supporting neighbours	confidence
▸	MAPK11	Q15759	2/20	0.40

▸	MAPK14	Q16539	2/20	0.40

▸	MAPK13	O15264	1/20	0.40

▸	MAPK12	P53778	1/20	0.40

▸	NQO2	P16083	1/20	0.40

▸	MAPKAPK2	P49137	1/20	0.40

▸	ACTR2	P61160	1/20	0.40

▸	CCR1	P32246	3/20	0.32

▸	CCR5	P51681	3/20	0.32

▸	ALOX5	P09917	1/20	0.32

▸	ADRB2	P07550	1/20	0.31

▸	ALDH1A1	P00352	1/20	0.31

▸	SMN1; SMN2	Q16637	1/20	0.31

▸	KDM4E	B2RXH2	1/20	0.30

▸	ALOX12	P18054	1/20	0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL14539804	0.92	MAPK14 (0.49)	MAPK11MAPK14MAPK13MAPK12NQO2
SCHEMBL14539721	0.91	MAPK14 (0.49)	MAPK11MAPK14MAPK13MAPK12NQO2
SCHEMBL4505052	0.88	MAPK14 (0.53)	MAPK11MAPK14MAPK13MAPK12NQO2
SCHEMBL14539786	0.82	MAPK14 (0.45)	MAPK11MAPK14MAPK13MAPK12NQO2
SCHEMBL13955063	0.80	MAPK14 (0.64)	MAPK11MAPK14MAPK13MAPK12NQO2
SCHEMBL4488618	0.80	MAPK14 (0.64)	MAPK11MAPK14MAPK13MAPK12NQO2
SCHEMBL4514087	0.80	MAPK14 (0.64)	MAPK11MAPK14MAPK13MAPK12NQO2
SCHEMBL4514094	0.80	MAPK14 (0.64)	MAPK11MAPK14MAPK13MAPK12NQO2
SCHEMBL4498276	0.78	MAPK14 (0.64)	MAPK11MAPK14MAPK13MAPK12NQO2
SCHEMBL14539716	0.78	MAPK14 (0.38)	MAPK11MAPK14MAPK13MAPK12NQO2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-7220763-B2	Indole-type derivatives as inhibitors of p38 kinase	SCIOS, INC. (US)	2007-05-22	—	—	US	disclosed