Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.45 |
| ▸ | NQO2 | P16083 | 1/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.45 |
| ▸ | ACTR2 | P61160 | 1/20 | 0.45 |
| ▸ | CCR1 | P32246 | 5/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | MLNR | O43193 | 3/20 | 0.34 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.34 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14539804 | 0.89 | MAPK14 (0.49) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL14539721 | 0.89 | MAPK14 (0.49) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL4503247 | 0.89 | MAPK14 (0.58) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL14539722 | 0.82 | MAPK11 (0.40) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL4488849 | 0.79 | MAPK14 (0.60) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL4495613 | 0.79 | MAPK14 (0.60) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL14539725 | 0.79 | MAPK14 (0.39) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL4514087 | 0.77 | MAPK14 (0.64) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL4498276 | 0.77 | MAPK14 (0.64) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL13955063 | 0.77 | MAPK14 (0.64) | MAPK14MAPK11MAPK13MAPK12NQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7220763-B2 | Indole-type derivatives as inhibitors of p38 kinase | SCIOS, INC. (US) | 2007-05-22 | — | — | US | disclosed |