Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 1/20 | 0.44 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 3/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14540935 | 0.87 | CCNK (0.44) | CCNKCDK12KDRPRMT5 | |
| SCHEMBL1894491 | 0.82 | FLT3 (0.54) | CSF1RFLT3KDRNPC1 | |
| SCHEMBL14540928 | 0.76 | KDM4E (0.47) | KDM4EMAPTALDH1A1HTTNPC1 | |
| SCHEMBL12499716 | 0.70 | FLT3 (0.56) | CSF1RFLT3KDR | |
| SCHEMBL4767556 | 0.69 | EGFR (0.51) | CSF1R | |
| SCHEMBL20840003 | 0.69 | CCNK (0.58) | CCNKCDK12CSF1RHTTFGFR1 | |
| SCHEMBL26686575 | 0.69 | CCNK (0.58) | CCNKCDK12CSF1RNPC1 | |
| SCHEMBL21611489 | 0.69 | SMN1; SMN2 (0.60) | KDM4EKDRHTTCYP1A2CYP3A4 | |
| SCHEMBL29631554 | 0.69 | SRC (0.60) | KDRFGFR1FGFR2 | |
| SCHEMBL1889950 | 0.67 | EIF2AK2 (0.61) | CSF1RHPGDPRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1777218-A1 | Process for the preparation of 4-phenoxy quinoline derivatives | Eisai R&D Management Co., Ltd. (JP) | 2007-04-25 | — | — | EP | disclosed |