Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.52 |
| ▸ | AURKA | O14965 | 8/20 | 0.52 |
| ▸ | TEK | Q02763 | 8/20 | 0.52 |
| ▸ | MET | P08581 | 6/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.52 |
| ▸ | LCK | P06239 | 6/20 | 0.51 |
| ▸ | FLT1 | P17948 | 3/20 | 0.51 |
| ▸ | LYN | P07948 | 1/20 | 0.51 |
| ▸ | AXL | P30530 | 2/20 | 0.49 |
| ▸ | RET | P07949 | 3/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.44 |
| ▸ | KIT | P10721 | 2/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.44 |
| ▸ | FLT4 | P35916 | 2/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.44 |
| ▸ | ERN1 | O75460 | 1/20 | 0.44 |
| ▸ | STK10 | O94804 | 1/20 | 0.44 |
| ▸ | MAP3K6 | O95382 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14540914 | 0.94 | KDR (0.58) | KDRAURKATEKMETAURKB | |
| SCHEMBL14540932 | 0.88 | AXL (0.51) | KDRAURKATEKMETAURKB | |
| SCHEMBL22505666 | 0.88 | KDR (0.52) | KDRAURKATEKMETAURKB | |
| SCHEMBL1892397 | 0.87 | AXL (0.51) | KDRAURKATEKMETAURKB | |
| SCHEMBL14540583 | 0.86 | KDR (0.54) | KDRAURKATEKMETAURKB | |
| SCHEMBL5364065 | 0.86 | AXL (0.50) | KDRAURKATEKMETAURKB | |
| SCHEMBL22505715 | 0.86 | AXL (0.59) | KDRAURKATEKMETAURKB | |
| SCHEMBL14540519 | 0.83 | KDR (0.61) | KDRAURKATEKMETAURKB | |
| SCHEMBL1897463 | 0.83 | FGFR4 (0.67) | KDRAURKATEKMETAURKB | |
| SCHEMBL14540588 | 0.82 | PDGFRA (0.48) | KDRAURKATEKMETAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1777218-A1 | Process for the preparation of 4-phenoxy quinoline derivatives | Eisai R&D Management Co., Ltd. (JP) | 2007-04-25 | — | — | EP | disclosed |