Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 12/20 | 0.57 |
| ▸ | MAPKAPK2 | P49137 | 7/20 | 0.57 |
| ▸ | GSK3B | P49841 | 5/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.49 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.49 |
| ▸ | PIM1 | P11309 | 3/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.42 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11930829 | 1.00 | CDK2 (0.57) | CDK2MAPKAPK2GSK3BCHEK1CCNA2 | |
| SCHEMBL11930830 | 1.00 | CDK2 (0.57) | CDK2MAPKAPK2GSK3BCHEK1CCNA2 | |
| SCHEMBL11930815 | 0.85 | CDK2 (0.47) | CDK2MAPKAPK2GSK3BCHEK1CCNA2 | |
| SCHEMBL11930884 | 0.81 | CDK2 (0.61) | CDK2MAPKAPK2GSK3BCHEK1CCNA2 | |
| SCHEMBL14051006 | 0.78 | PIM1 (0.43) | CDK2MAPKAPK2GSK3BCHEK1CCNA2 | |
| SCHEMBL14051004 | 0.78 | PIM1 (0.43) | CDK2MAPKAPK2GSK3BCHEK1CCNA2 | |
| SCHEMBL11930841 | 0.76 | CDK2 (0.44) | CDK2MAPKAPK2GSK3BCHEK1CCNA2 | |
| SCHEMBL11930844 | 0.76 | CDK2 (0.44) | CDK2MAPKAPK2GSK3BCHEK1CCNA2 | |
| SCHEMBL11930825 | 0.75 | CDK2 (0.47) | CDK2MAPKAPK2GSK3BCHEK1CCNA2 | |
| SCHEMBL14427517 | 0.74 | CDK2 (0.70) | CDK2MAPKAPK2GSK3BCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044441-A2 | USE OF PYRAZOLO [1 , 5 -A] PYRIMIDINE DERIVATIVES FOR INHIBITING PROTEIN KINASES METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |