Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 14/20 | 0.67 |
| ▸ | CDK2 | P24941 | 3/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.55 |
| ▸ | CDK9 | P50750 | 2/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13146324 | 0.92 | GSK3B (0.77) | GSK3BCDK2CHEK1CCNE1 | |
| SCHEMBL13304869 | 0.90 | GSK3B (0.77) | GSK3BCDK2CHEK1CCNE1 | |
| SCHEMBL13305208 | 0.89 | GSK3B (0.85) | GSK3BCDK2CCNE1 | |
| SCHEMBL13305370 | 0.88 | GSK3B (0.61) | GSK3BCDK2CHEK1CCNE1 | |
| SCHEMBL13289362 | 0.88 | GSK3B (0.61) | GSK3BCDK2CHEK1CCNE1 | |
| SCHEMBL13305374 | 0.88 | GSK3B (0.61) | GSK3BCDK2CHEK1CDK9CCNE1 | |
| SCHEMBL13289858 | 0.88 | GSK3B (0.68) | GSK3BCDK2CHEK1CCNE1 | |
| SCHEMBL12954148 | 0.88 | GSK3B (0.66) | GSK3BCDK2CHEK1CCNE1 | |
| SCHEMBL13289618 | 0.88 | GSK3B (0.59) | GSK3BCDK2CHEK1CCNE1 | |
| SCHEMBL14301241 | 0.88 | GSK3B (0.61) | GSK3BCDK2CHEK1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044449-A2 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |