Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 6/20 | 0.36 |
| ▸ | CDK2 | P24941 | 8/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.33 |
| ▸ | FEN1 | P39748 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14613413 | 0.89 | GSK3B (0.36) | GSK3BCDK2CCNA2CCNA1KDM4E | |
| SCHEMBL14613281 | 0.86 | GSK3B (0.37) | GSK3BCDK2CCNA2CCNA1KDM4E | |
| SCHEMBL12954494 | 0.86 | GSK3B (0.42) | GSK3BCDK2CCNA2CCNA1ALOX5AP | |
| SCHEMBL12953984 | 0.85 | NPY5R (0.41) | CDK2KDM4EMEN1KMT2ANPY5R | |
| SCHEMBL13288981 | 0.85 | CDK2 (0.46) | GSK3BCDK2CCNA2CCNA1KDM4E | |
| SCHEMBL14613411 | 0.83 | GSK3B (0.33) | GSK3BCDK2CCNA2CCNA1KDM4E | |
| SCHEMBL13289301 | 0.83 | CDK2 (0.46) | GSK3BCDK2KDM4ENPC1MAPT | |
| SCHEMBL14613280 | 0.83 | MEN1 (0.45) | GSK3BCDK2CCNA2CCNA1KDM4E | |
| SCHEMBL13289056 | 0.82 | F13A1 (0.36) | GSK3BCDK2CCNA2CCNA1KDM4E | |
| SCHEMBL13289271 | 0.82 | MMP2 (0.44) | GSK3BCA12CA2CA9MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044449-A2 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |