Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | BRAF | P15056 | 8/20 | 0.49 |
| ▸ | KDR | P35968 | 4/20 | 0.48 |
| ▸ | LCK | P06239 | 3/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.48 |
| ▸ | TEK | Q02763 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | APEX1 | P27695 | 2/20 | 0.47 |
| ▸ | RAF1 | P04049 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 2/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | ESYT2 | A0FGR8 | 1/20 | 0.42 |
| ▸ | HACL2 | A1L0T0 | 1/20 | 0.42 |
| ▸ | NBAS | A2RRP1 | 1/20 | 0.42 |
| ▸ | GTPBP10 | A4D1E9 | 1/20 | 0.42 |
| ▸ | CNOT1 | A5YKK6 | 1/20 | 0.42 |
| ▸ | TBKBP1 | A7MCY6 | 1/20 | 0.42 |
| ▸ | AGPS | O00116 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1454904 | 0.91 | POLB (0.51) | POLBBRAFKDRLCKMAPK14 | |
| SCHEMBL1454672 | 0.90 | BRAF (0.48) | POLBBRAFKDRAURKAABL1 | |
| SCHEMBL1454720 | 0.89 | PIM1 (0.44) | BRAFKDRMAPK14TEKRAF1 | |
| SCHEMBL1455176 | 0.87 | POLB (0.49) | POLBBRAFKDRLCKMAPK14 | |
| SCHEMBL1455179 | 0.86 | KCNQ3 (0.45) | BRAFKDRAURKAALDH1A1LMNA | |
| SCHEMBL1454780 | 0.85 | PIM1 (0.45) | BRAFKDRTEKAURKAABL1 | |
| SCHEMBL1454471 | 0.84 | PIM1 (0.42) | POLBBRAFMAPK14PIM1AKT2 | |
| SCHEMBL1454908 | 0.83 | EGFR (0.48) | POLBBRAFKDRMAPTCSF1R | |
| SCHEMBL1455417 | 0.83 | BRAF (0.46) | BRAFKDRMAPK14MAPTKDM4E | |
| SCHEMBL1455215 | 0.83 | PIM1 (0.41) | BRAFMAPK14AURKAABL1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979348-B1 | ANTI-VIRAL COMPOUNDS | ABBOTT LAB (US) | 2012-01-18 | — | — | EP | disclosed |
| US-7910595-B2 | Anti-viral compounds | ABBOTT LABORATORIES (US) | 2011-03-22 | — | — | US | disclosed |
| EP-1979348-A2 | ANTI-VIRAL COMPOUNDS | Abbott Laboratories (US) | 2008-10-15 | — | — | EP | disclosed |
| US-20070232627-A1 | ANTI-VIRAL COMPOUNDS | ABBVIE INC. | 2007-10-04 | — | — | US | disclosed |
| WO-2007076034-A2 | ANTI-VIRAL COMPOUNDS | ABBOTT LABORATORIES (US) | 2007-07-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232627-A1 | ANTI-VIRAL COMPOUNDS | HAVCR2, MAVS, EIF2AK2 | POLB 442/4885BRAF 4226/4885KDR 3293/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.