Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 14/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 13/20 | 0.44 |
| ▸ | CDK2 | P24941 | 13/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 13/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11930783 | 0.89 | CHEK1 (0.45) | NPC1RAB9ACHEK1CCNA2CDK2 | |
| SCHEMBL14050871 | 0.80 | NPC1 (0.40) | NPC1RAB9ACHEK1CCNA2CDK2 | |
| SCHEMBL11930911 | 0.73 | CHEK1 (0.57) | CHEK1CCNA2CDK2CCNA1RPS6KA4 | |
| SCHEMBL12404064 | 0.72 | CHEK1 (0.50) | NPC1RAB9ACHEK1CCNA2CDK2 | |
| SCHEMBL11930796 | 0.71 | CHEK1 (0.49) | NPC1RAB9ACHEK1CCNA2CDK2 | |
| SCHEMBL14231848 | 0.70 | CHEK1 (0.41) | CHEK1CCNA2CDK2CCNA1RPS6KA4 | |
| SCHEMBL14539667 | 0.70 | SMPD3 (0.41) | NPC1RAB9ACHEK1CCNA2CDK2 | |
| SCHEMBL11930770 | 0.70 | CHEK1 (0.73) | CHEK1CCNA2CDK2CCNA1RPS6KA4 | |
| SCHEMBL14539665 | 0.69 | CHEK1 (0.43) | NPC1RAB9ACHEK1CCNA2CDK2 | |
| SCHEMBL14545940 | 0.69 | SMPD3 (0.40) | NPC1RAB9ACHEK1CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044449-A2 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |