Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 8/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 4/20 | 0.40 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14418841 | 0.91 | GSK3B (0.53) | GSK3BCHEK1ALDH1A1LMNAKMT2A | |
| SCHEMBL13120568 | 0.91 | GSK3B (0.65) | GSK3BCDK2CCNE1 | |
| SCHEMBL14607248 | 0.91 | GSK3B (0.53) | GSK3BCHEK1USP2ALDH1A1LMNA | |
| SCHEMBL14418705 | 0.91 | GSK3B (0.53) | GSK3BCHEK1KMT2ACDK2CCNE1 | |
| SCHEMBL13289368 | 0.91 | GSK3B (0.56) | GSK3BCHEK1CDK2CCNE1 | |
| SCHEMBL14301576 | 0.89 | GSK3B (0.52) | GSK3BCHEK1USP2ALDH1A1LMNA | |
| SCHEMBL12953940 | 0.89 | GSK3B (0.53) | GSK3BCHEK1USP2ALDH1A1LMNA | |
| SCHEMBL12953062 | 0.89 | GSK3B (0.58) | GSK3BCHEK1CDK2CCNE1 | |
| SCHEMBL14301590 | 0.87 | GSK3B (0.55) | GSK3BCHEK1USP2ALDH1A1LMNA | |
| SCHEMBL14307164 | 0.87 | GSK3B (0.51) | GSK3BCHEK1ALDH1A1KMT2ACDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044449-A2 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |