Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 7/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14301590 | 0.94 | GSK3B (0.55) | GSK3BCHEK1NAMPTLMNAUSP2 | |
| SCHEMBL14043442 | 0.93 | GSK3B (0.57) | GSK3BCHEK1NAMPTLMNAUSP2 | |
| SCHEMBL14043358 | 0.93 | GSK3B (0.53) | GSK3BCHEK1NAMPTLMNAUSP2 | |
| SCHEMBL14418704 | 0.93 | GSK3B (0.53) | GSK3BCHEK1NAMPTLMNAUSP2 | |
| SCHEMBL13289378 | 0.92 | GSK3B (0.53) | GSK3BCHEK1NAMPTLMNAALDH1A1 | |
| SCHEMBL13120571 | 0.91 | GSK3B (0.66) | GSK3BLMNAMEN1MAPK1KMT2A | |
| SCHEMBL14301572 | 0.90 | GSK3B (0.52) | GSK3BCHEK1NAMPTLMNAUSP2 | |
| SCHEMBL12953062 | 0.89 | GSK3B (0.58) | GSK3BCHEK1 | |
| SCHEMBL14545843 | 0.89 | GSK3B (0.53) | GSK3BCHEK1NAMPTLMNAUSP2 | |
| SCHEMBL14581372 | 0.88 | GSK3B (0.52) | GSK3BCHEK1NAMPTLMNAUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720882-B1 | PYRAZOLOPYRIMIDINE-DERIVATIVES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2011-01-05 | — | — | EP | disclosed |