Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 0.50 |
| ▸ | CDK2 | P24941 | 10/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13120284 | 0.91 | CDK2 (0.60) | GSK3BCDK2CCNE1CCNA2CCNA1 | |
| SCHEMBL13120075 | 0.86 | CDK2 (0.58) | GSK3BCDK2CCNE1CCNA2CCNA1 | |
| SCHEMBL13120150 | 0.86 | CDK2 (0.58) | GSK3BCDK2CCNE1CCNA2CCNA1 | |
| SCHEMBL13120304 | 0.84 | CDK2 (0.58) | GSK3BCDK2CCNE1 | |
| SCHEMBL13120264 | 0.84 | CDK2 (0.60) | GSK3BCDK2CCNE1CCNA2CCNA1 | |
| SCHEMBL13120278 | 0.83 | GSK3B (0.57) | GSK3BCDK2CCNE1CCNA2CCNA1 | |
| SCHEMBL13120285 | 0.83 | GSK3B (0.57) | GSK3BCDK2CCNE1CCNA2CCNA1 | |
| SCHEMBL14561755 | 0.83 | GSK3B (0.56) | GSK3BCDK2CCNE1CCNA2CCNA1 | |
| SCHEMBL13120302 | 0.83 | CDK2 (0.57) | GSK3BCDK2CCNE1CCNA2CCNA1 | |
| SCHEMBL13120297 | 0.82 | CDK2 (0.58) | GSK3BCDK2CCNE1CCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044449-A2 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |