Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 10/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14301575 | 0.95 | GSK3B (0.53) | GSK3BCHEK1CDK2SMN1; SMN2LMNA | |
| SCHEMBL13289011 | 0.92 | GSK3B (0.56) | GSK3BCHEK1CDK2CCNE1 | |
| SCHEMBL14301574 | 0.91 | GSK3B (0.51) | GSK3BCHEK1CDK2SMN1; SMN2LMNA | |
| SCHEMBL14301589 | 0.91 | GSK3B (0.53) | GSK3BCHEK1CDK2SMN1; SMN2LMNA | |
| SCHEMBL13120619 | 0.91 | GSK3B (0.65) | GSK3BCDK2CCNE1 | |
| SCHEMBL14607248 | 0.90 | GSK3B (0.53) | GSK3BCHEK1CDK2SMN1; SMN2LMNA | |
| SCHEMBL14581372 | 0.89 | GSK3B (0.52) | GSK3BCHEK1CDK2SMN1; SMN2LMNA | |
| SCHEMBL14301572 | 0.89 | GSK3B (0.52) | GSK3BCHEK1CDK2SMN1; SMN2LMNA | |
| SCHEMBL14301576 | 0.89 | GSK3B (0.52) | GSK3BCHEK1CDK2SMN1; SMN2LMNA | |
| SCHEMBL14301590 | 0.87 | GSK3B (0.55) | GSK3BCHEK1SMN1; SMN2LMNAUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044449-A2 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |