Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14301572 | 0.91 | GSK3B (0.52) | GSK3BSMN1; SMN2CHEK1LMNAALDH1A1 | |
| SCHEMBL13120584 | 0.91 | GSK3B (0.64) | GSK3BCDK2 | |
| SCHEMBL14418706 | 0.91 | GSK3B (0.52) | GSK3BSMN1; SMN2CHEK1LMNAALDH1A1 | |
| SCHEMBL12953928 | 0.91 | GSK3B (0.55) | GSK3BSMN1; SMN2CHEK1LMNACDK2 | |
| SCHEMBL14301575 | 0.90 | GSK3B (0.53) | GSK3BSMN1; SMN2CHEK1LMNAALDH1A1 | |
| SCHEMBL14301590 | 0.90 | GSK3B (0.55) | GSK3BSMN1; SMN2CHEK1LMNAALDH1A1 | |
| SCHEMBL12954478 | 0.90 | GSK3B (0.50) | GSK3BSMN1; SMN2CHEK1LMNAALDH1A1 | |
| SCHEMBL14301574 | 0.89 | GSK3B (0.51) | GSK3BSMN1; SMN2CHEK1LMNAALDH1A1 | |
| SCHEMBL14546002 | 0.89 | GSK3B (0.53) | GSK3BSMN1; SMN2CHEK1LMNAALDH1A1 | |
| SCHEMBL14301576 | 0.89 | GSK3B (0.52) | GSK3BSMN1; SMN2CHEK1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070054925-A1 | Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION | 2007-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070054925-A1 | Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors | CDK2, CDK1, CDKN1A | GSK3B 695/4885SMN1; SMN2 2337/4885CHEK1 60/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.