Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.74 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.74 |
| ▸ | TSHR | P16473 | 2/20 | 0.74 |
| ▸ | THPO | P40225 | 2/20 | 0.74 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.74 |
| ▸ | GLA | P06280 | 1/20 | 0.74 |
| ▸ | EIF4E | P06730 | 1/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.74 |
| ▸ | TOP1 | P11387 | 1/20 | 0.74 |
| ▸ | PNP | P00491 | 3/20 | 0.57 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | BLM | P54132 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15031296 | 0.91 | LMNA (0.74) | LMNASMN1; SMN2ADORA1ALDH1A1TSHR | |
| SCHEMBL13524851 | 0.89 | LMNA (0.58) | LMNASMN1; SMN2ADORA1ALDH1A1TSHR | |
| SCHEMBL13524854 | 0.89 | LMNA (0.58) | LMNASMN1; SMN2ADORA1ALDH1A1TSHR | |
| Ribavirin SCHEMBL6027558 | 0.85 | LMNA (1.00) | LMNASMN1; SMN2ADORA1ALDH1A1TSHR | |
| Ribavirin SCHEMBL5476700 | 0.85 | LMNA (1.00) | LMNASMN1; SMN2ADORA1ALDH1A1TSHR | |
| Ribavirin SCHEMBL3727 | 0.85 | LMNA (1.00) | LMNASMN1; SMN2ADORA1ALDH1A1TSHR | |
| Ribavirin SCHEMBL2619251 | 0.85 | LMNA (1.00) | LMNASMN1; SMN2ADORA1ALDH1A1TSHR | |
| Ribavirin SCHEMBL20806078 | 0.85 | LMNA (1.00) | LMNASMN1; SMN2ADORA1ALDH1A1TSHR | |
| Ribavirin SCHEMBL21311208 | 0.85 | LMNA (1.00) | LMNASMN1; SMN2ADORA1ALDH1A1TSHR | |
| Ribavirin SCHEMBL12658449 | 0.85 | LMNA (1.00) | LMNASMN1; SMN2ADORA1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070087960-A1 | Treating hepatitis C virus infections; antivirals have low toxicity to the host; inhibit Flaviviridae polymerase | IDENIX PHARMACEUTICALS LLC | 2007-04-19 | — | — | US | disclosed |
| US-20070060541-A1 | 2' and 3'-nucleoside prodrugs for treating Flaviviridae infections | IDENIX PHARMACEUTICALS, INC. | 2007-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060541-A1 | 2' and 3'-nucleoside prodrugs for treating Flaviviridae infections | PNP, NSUN2, HAVCR2 | LMNA 981/4885SMN1; SMN2 626/4885ADORA1 419/4885 |
| US-20070087960-A1 | Treating hepatitis C virus infections; antivirals have low toxicity to the host; inhibit Flaviviridae polymerase | HAVCR2, UGT1A3, UGT1A1 | LMNA 2662/4885SMN1; SMN2 2478/4885ADORA1 635/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.