Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 19/20 | 0.48 |
| ▸ | CCND1 | P24385 | 18/20 | 0.48 |
| ▸ | CDK2 | P24941 | 9/20 | 0.48 |
| ▸ | CDK6 | Q00534 | 5/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.48 |
| ▸ | CDK9 | P50750 | 1/20 | 0.48 |
| ▸ | CCND2 | P30279 | 8/20 | 0.44 |
| ▸ | CCND3 | P30281 | 8/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.43 |
| ▸ | CDK1 | P06493 | 2/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 6/20 | 0.42 |
| ▸ | FGFR4 | P22455 | 6/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 6/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14547323 | 0.96 | CDK4 (0.44) | CDK4CCND1CDK2CDK6CCNE1 | |
| SCHEMBL14547180 | 0.93 | CDK4 (0.54) | CDK4CCND1CDK2CDK6CCNE1 | |
| SCHEMBL4227763 | 0.84 | CDK4 (0.51) | CDK4CCND1CDK2CDK6CCNE1 | |
| SCHEMBL4220812 | 0.80 | PIK3CA (0.56) | CDK4CCND1CDK2CDK6CCNE1 | |
| SCHEMBL4226220 | 0.79 | PIK3CA (0.49) | CDK4CCND1CDK2CDK6CCNE1 | |
| SCHEMBL12102037 | 0.78 | CDK4 (0.46) | CDK4CCND1CDK2CDK6CCNE1 | |
| SCHEMBL3337709 | 0.77 | CDK4 (0.59) | CDK4CCND1CDK2CDK6CCNE1 | |
| SCHEMBL4225857 | 0.76 | PIK3CA (0.45) | CDK4CCND1CDK2CDK6CCNE1 | |
| SCHEMBL4222668 | 0.76 | PIK3CA (0.45) | CDK4CCND1CDK2CDK6CCNE1 | |
| SCHEMBL4232744 | 0.76 | PIK3CA (0.45) | CDK4CCND1CDK2CDK6CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044698-A1 | PYRIDOPYRIMIDINONE INHIBITORS OF PI3Kα | EXELIXIS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |