Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 1/20 | 0.57 |
| ▸ | KCNH3 | Q9ULD8 | 7/20 | 0.56 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.56 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.48 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.48 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 1/20 | 0.47 |
| ▸ | TTK | P33981 | 1/20 | 0.46 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14547770 | 0.85 | PTK2 (0.53) | PAK4PTK2TTBK1TTBK2TTK | |
| SCHEMBL5119258 | 0.81 | LRRK2 (0.65) | PAK4PTK2TTBK1TTBK2TTK | |
| SCHEMBL4920915 | 0.81 | JAK2 (0.50) | PAK4IRAK4PTK2JAK1TTK | |
| SCHEMBL19010671 | 0.81 | JAK2 (0.40) | PAK4IRAK4PTK2JAK1TTK | |
| SCHEMBL14287376 | 0.80 | PTK2 (0.69) | PAK4PTK2TTBK1TTBK2TTK | |
| SCHEMBL14547712 | 0.80 | SYK (0.64) | PAK4IRAK4PTK2JAK1TTK | |
| SCHEMBL22587420 | 0.77 | ACP1 (0.64) | — | |
| SCHEMBL28456343 | 0.76 | TAAR1 (0.66) | PAK4KCNH3IRAK4 | |
| SCHEMBL2052097 | 0.76 | PTK2 (0.56) | PAK4IRAK4PTK2JAK1TTK | |
| SCHEMBL10169192 | 0.75 | LRRK2 (0.44) | PAK4PTK2TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007042299-A1 | PYRROLOPYRIMIDINE DERIVATIVES AS SYK INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-04-19 | — | — | WO | disclosed |