Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 12/20 | 0.56 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.51 |
| ▸ | JAK3 | P52333 | 3/20 | 0.51 |
| ▸ | BTK | Q06187 | 3/20 | 0.51 |
| ▸ | JAK2 | O60674 | 2/20 | 0.51 |
| ▸ | ABL1 | P00519 | 2/20 | 0.51 |
| ▸ | INSR | P06213 | 2/20 | 0.51 |
| ▸ | LCK | P06239 | 2/20 | 0.51 |
| ▸ | FYN | P06241 | 2/20 | 0.51 |
| ▸ | RET | P07949 | 2/20 | 0.51 |
| ▸ | MST1 | P26927 | 2/20 | 0.51 |
| ▸ | TTK | P33981 | 2/20 | 0.51 |
| ▸ | SYK | P43405 | 2/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.51 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.51 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.51 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.51 |
| ▸ | SGK1 | O00141 | 1/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14547779 | 0.92 | LRRK2 (0.58) | LRRK2PTK2JAK3BTKJAK2 | |
| SCHEMBL14547937 | 0.91 | LRRK2 (0.55) | LRRK2PTK2JAK3BTKJAK2 | |
| SCHEMBL14547945 | 0.90 | LRRK2 (0.56) | LRRK2PTK2JAK3BTKJAK2 | |
| SCHEMBL14547785 | 0.83 | LRRK2 (0.58) | LRRK2PTK2JAK3BTKJAK2 | |
| SCHEMBL14547929 | 0.82 | LRRK2 (0.63) | LRRK2PTK2JAK3BTKJAK2 | |
| SCHEMBL14547717 | 0.82 | LRRK2 (0.62) | LRRK2PTK2JAK3BTKJAK2 | |
| SCHEMBL14547974 | 0.81 | LRRK2 (0.55) | LRRK2PTK2JAK3BTKJAK2 | |
| SCHEMBL14547777 | 0.80 | PTK2 (0.65) | LRRK2PTK2JAK3BTKJAK2 | |
| SCHEMBL14547851 | 0.79 | LRRK2 (0.59) | LRRK2PTK2JAK3BTKJAK2 | |
| SCHEMBL14287420 | 0.79 | LRRK2 (0.72) | LRRK2PTK2JAK3BTKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007042299-A1 | PYRROLOPYRIMIDINE DERIVATIVES AS SYK INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-04-19 | — | — | WO | disclosed |