Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 14/20 | 0.55 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.51 |
| ▸ | JAK3 | P52333 | 5/20 | 0.51 |
| ▸ | JAK2 | O60674 | 4/20 | 0.51 |
| ▸ | ABL1 | P00519 | 4/20 | 0.51 |
| ▸ | RET | P07949 | 4/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.51 |
| ▸ | MAP4K2 | Q12851 | 4/20 | 0.51 |
| ▸ | NTRK2 | Q16620 | 4/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.51 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.51 |
| ▸ | AURKA | O14965 | 3/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.51 |
| ▸ | PAK4 | O96013 | 3/20 | 0.51 |
| ▸ | CSF1R | P07333 | 3/20 | 0.51 |
| ▸ | LTK | P29376 | 3/20 | 0.51 |
| ▸ | KDR | P35968 | 3/20 | 0.51 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.51 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14547785 | 0.93 | LRRK2 (0.58) | LRRK2PTK2JAK3JAK2ABL1 | |
| SCHEMBL14547932 | 0.91 | LRRK2 (0.56) | LRRK2PTK2JAK3JAK2ABL1 | |
| SCHEMBL14547974 | 0.90 | LRRK2 (0.55) | LRRK2PTK2JAK3JAK2ABL1 | |
| SCHEMBL14547779 | 0.83 | LRRK2 (0.58) | LRRK2PTK2JAK3JAK2ABL1 | |
| SCHEMBL14547718 | 0.82 | LRRK2 (0.61) | LRRK2PTK2JAK3JAK2ABL1 | |
| SCHEMBL14547945 | 0.81 | LRRK2 (0.56) | LRRK2PTK2JAK3JAK2ABL1 | |
| SCHEMBL14547857 | 0.80 | PTK2 (0.64) | LRRK2PTK2JAK3JAK2ABL1 | |
| SCHEMBL14547856 | 0.80 | LRRK2 (0.58) | LRRK2PTK2JAK3JAK2ABL1 | |
| SCHEMBL14547767 | 0.79 | PTK2 (0.75) | LRRK2PTK2JAK3JAK2ABL1 | |
| SCHEMBL14547719 | 0.78 | PTK2 (0.59) | LRRK2PTK2JAK3JAK2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007042299-A1 | PYRROLOPYRIMIDINE DERIVATIVES AS SYK INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-04-19 | — | — | WO | disclosed |